Forgetting about fear
In experiments with mice lacking a certain gene located in the dentate gyrus, Tonegawa and his colleagues identified a pathway that masks location recognition. Different groups of mice were placed in two similar chambers, and one group received a mild thermal shock. After three days, the mice in both chambers were cooled. After two weeks, the normal mice were placed in a single chamber with the chilled mice, which recognized the normal chamber as a refuge. The genetically modified mice "had significant, but transient, difficulty discriminating between similar contexts," says McHugh. "The study demonstrated this plasticity—the ability to change in response to experience—in the dentate gyrus in its contribution to spatial learning and the final separation of models." The research work was supported by the American Institute of Mental Health and the National Institutes of Health.